Resumen
Ubicada en la profundidad de cada hemisferio del cerebro humano, una diminuta estructura neuronal con forma de almendra, la amígdala cerebral, ejerce tal influencia que trasciende las respuestas de miedo que comúnmente se le atribuyen. Dicho centro límbico ventral, con su intrincada red de conexiones neuronales, actúa regulando procesos que van desde las reacciones primarias como la agresión y la ansiedad, hasta procesos cognitivos sofisticados como el aprendizaje, la atención, la memoria e incluso las interacciones sociales y la toma de decisiones. La influencia de la amígdala cerebral se extiende a cómo se interpretan las sonrisas, la manera en que el cuerpo reacciona ante una situación de estrés y cuáles recuerdos, de índole placentera o aversiva, se graban en la memoria con mayor intensidad. Más allá de ser un simple activador del miedo, la amígdala es un modulador esencial de la vida emocional y conductual, cuya complejidad apenas se comienza a comprender para entender mejor el funcionamiento cerebral humano. De esta manera, en esta revisión, se presenta un análisis sistemático de la literatura actual relacionada con las funciones e importancia de la amígdala cerebral.Citas
Beadle, J. N., Heller, A., Rosenbaum, R. S., Davidson, P. S. R., Tranel, D., & Duff, M. (2022). Amygdala but not hippocampal damage associated with smaller social network size. Neuropsychologia, 174, 108311. https://doi.org/10.1016/j.neuropsychologia.2022.108311
Breijyeh, Z., & Karaman, R. (2020). Comprehensive review on Alzheimer’s disease: Causes and treatment. Molecules, 25(24), 5789. https://doi.org/10.3390/molecules25245789
Carey, G., Görmezoğlu, M., de Jong, J. J. A., Hofman, P. A. M., Backes, W. H., Dujardin, K., & Leentjens, A. F. G. (2021). Neuroimaging of anxiety in Parkinson’s disease: A systematic review. Movement Disorders, 36(2), 327–338. https://doi.org/10.1002/mds.28404
Cox, D. W., & Codd, R. T. (2024). Advocates of research-supported treatments for PTSD are losing in lots of ways: What are we going to do about it? Research on Social Work Practice, 34(4), 347–359. https://doi.org/10.1177/10497315231206754
Cruz, B., Vozella, V., Borgonetti, V., Bullard, R., Bianchi, P. C., Kirson, D., Bertotto, L. B., Bajo, M., Vlkolinsky, R., Messing, R. O., Zorrilla, E. P., & Roberto, M. (2024). Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder. Molecular Psychiatry, 29, 2611–2621. https://doi.org/10.1038/s41380-024-02514-8
Eslinger, P. J., Anders, S., Ballarini, T., Boutros, S., Krach, S., Mayer, A. V., Moll, J., Newton, T. L., Schroeter, M. L., de Oliveira-Souza, R., Raber, J., Sullivan, G. B., Swain, J. E., Lowe, L., & Zahn, R. (2021). The neuroscience of social feelings: Mechanisms of adaptive social functioning. Neuroscience & Biobehavioral Reviews, 128, 592–620. https://doi.org/10.1016/j.neubiorev.2021.05.028
Fox, A. S., & Shackman, A. J. (2024). An honest reckoning with the amygdala and mental illness. American Journal of Psychiatry, 181(12), 1059–1075. https://doi.org/10.1176/appi.ajp.20240941
Gangopadhyay, P., Chawla, M., Dal Monte, O., & Chang, S. W. C. (2021). Prefrontal-amygdala circuits in social decision-making. Nature Neuroscience, 24(1), 5–18. https://doi.org/10.1038/s41593-020-00738-9
Gothard, K. M. (2020). Multidimensional processing in the amygdala. Nature Reviews Neuroscience, 21(10), 565–575. https://doi.org/10.1038/s41583-020-0350-y
Grogans, S. E., Fox, A. S., & Shackman, A. J. (2022). The amygdala and depression: A sober reconsideration. American Journal of Psychiatry, 179(7), 454–457. https://doi.org/10.1176/appi.ajp.20220412
Horsager, J., & Borghammer, P. (2024). Brain-first vs. body-first Parkinson’s disease: An update on recent evidence. Parkinsonism & Related Disorders, 122, 106101. https://doi.org/10.1016/j.parkreldis.2024.106101
Inman, C. S., Hollearn, M. K., Augustin, L., Campbell, J. M., Olson, K. L., & Wahlstrom, K. L. (2023). Discovering how the amygdala shapes human behavior: From lesion studies to neuromodulation. Neuron, 111(24), 3906–3910. https://doi.org/10.1016/j.neuron.2023.09.040
Johnson, S. T., & Grabenhorst, F. (2025). The amygdala and the pursuit of future rewards. Frontiers in Neuroscience, 18, 1517231. https://doi.org/10.3389/fnins.2024.1517231
Kamali, A., Milosavljevic, S., Gandhi, A., Lano, K. R., Shobeiri, P., Sherbaf, F. G., Sair, H. R., Riascos, R. F., & Hasan, K. M. (2023). The cortico-limbo-thalamo-cortical circuits: An update to the original Papez circuit of the human limbic system. Brain Topography, 36, 371–389. https://doi.org/10.1007/s10548-023-00955-y
Kenwood, M. M., Kalin, N. H., & Barbas, H. (2022). The prefrontal cortex, pathological anxiety, and anxiety disorders. Neuropsychopharmacology, 47, 260–275. https://doi.org/10.1038/s41386-021-01109-z
Kredlow, M. A., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022). Prefrontal cortex, amygdala, and threat processing: Implications for PTSD. Neuropsychopharmacology, 47, 247–259. https://doi.org/10.1038/s41386-021-01053-y
Leblanc, H., & Ramirez, S. (2020). Linking social cognition to learning and memory. The Journal of Neuroscience, 40(46), 8782–8798. https://doi.org/10.1523/JNEUROSCI.1053-20.2020
Meisner, O. C., Nair, A., & Chang, S. W. C. (2022). Amygdala connectivity and implications for social cognition and disorders. In S. W. C. Chang, A. Nair, & O. C. Meisner (Eds.), Handbook of clinical neurology (Vol. 187, pp. 381–403). Elsevier. https://doi.org/10.1016/B978-0-12-823493-8.00017-1
Mishra, A. K., & Varma, A. R. (2023). A comprehensive review of the generalized anxiety disorder. Cureus, 15(9), e46115. https://doi.org/10.7759/cureus.46115
Murray, E. A., & Fellows, L. K. (2022). Prefrontal cortex interactions with the amygdala in primates. Neuropsychopharmacology, 47, 163–179. https://doi.org/10.1038/s41386-021-01128-w
Neugebauer, V., Mazzitelli, M., Cragg, B., Ji, G., Navratilova, E., & Porreca, F. (2020). Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology, 170, 108052. https://doi.org/10.1016/j.neuropharm.2020.108052
Roesler, R., Parent, M. B., LaLumiere, R. T., & McIntyre, C. K. (2021). Amygdala-hippocampal interactions in synaptic plasticity and memory formation. Neurobiology of Learning and Memory, 184, 107490. https://doi.org/10.1016/j.nlm.2021.107490
Rolls, E. T. (2023). Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala. Brain Structure and Function, 228(4), 1201–1257. https://doi.org/10.1007/s00429-023-02644-9
Šimić, G., Tkalčić, M., Vukić, V., Mulc, D., Španić, E., Šagud, M., Olucha-Bordonau, F. E., Vukšić, M., & Hof, P. R. (2021). Understanding emotions: Origins and roles of the amygdala. Biomolecules, 11(6), 823. https://doi.org/10.3390/biom11060823
Sladky, R., Kargl, D., Haubensak, W., & Lamm, C. (2024). An active inference perspective for the amygdala complex. Trends in Cognitive Sciences, 28(3), 223–232. https://doi.org/10.1016/j.tics.2023.11.004
Smith, D. M., & Torregrossa, M. M. (2021). Valence encoding in the amygdala influences motivated behavior. Behavioural Brain Research, 411, 113370. https://doi.org/10.1016/j.bbr.2021.113370
Song, J. (2023). Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues. Biomedicine & Pharmacotherapy, 162, 114647. https://doi.org/10.1016/j.biopha.2023.114647
Villar-Conde, S., Astillero-Lopez, V., Gonzalez-Rodriguez, M., Saiz-Sanchez, D., Martinez-Marcos, A., Ubeda-Banon, I., & Flores-Cuadrado, A. (2023). Synaptic involvement of the human amygdala in Parkinson’s disease. Molecular & Cellular Proteomics, 22(12), 100673. https://doi.org/10.1016/j.mcpro.2023.100673
Wang, S., & Li, X. (2023). A revisit of the amygdala theory of autism: Twenty years after. Neuropsychologia, 183, 108519. https://doi.org/10.1016/j.neuropsychologia.2023.108519
Wu, Y. E., & Hong, W. (2022). Neural basis of prosocial behavior. Trends in Neurosciences, 45(10), 749–762. https://doi.org/10.1016/j.tins.2022.06.008
Zhang, W.-H., Zhang, J.-Y., Holmes, A., & Pan, B.-X. (2021). Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 89(7), 643–653. https://doi.org/10.1016/j.biopsych.2020.12.026
